Children who receive higher levels of Vitamin D during infancy and childhood may be significantly at a lower risk of developing islet autoimmunity as well as Type 1 diabetes, according to a study. Type 1 diabetes is a chronic autoimmune disease that is increasing by 3-5% annually worldwide and occurs when the body’s immune system destroys its own insulin-producing beta cells in the pancreas. Bear in mind that over 80% of people in India are deficient in Vitamin D.
Islet autoimmunity, detected by antibodies that appear when the immune system attacks the islet cells in the pancreas that produce insulin, is a precursor to Type 1 diabetes. Vitamin D represents a candidate protective factor for Type 1 diabetes as it regulates the immune system and autoimmunity, the researchers said.
“For several years, there has been controversy among scientists about whether Vitamin D lowers the risk of developing of islet autoimmunity and Type 1 diabetes,” said lead author Jill Norris from the Colorado University — Anschutz.
In the study, published in the journal Diabetes, the team searched for triggers and protective factors in 8,676 children with elevated Type 1 diabetes risk. They identified islet autoimmunity in 376 children and compared them with 1,041 children who did not.
Among children who were at an increased genetic risk for Type 1 diabetes, those with lower Vitamin D levels in infancy and childhood went on to develop islet autoimmunity compared with those who did not develop autoimmunity. The study showed that higher childhood vitamin D levels are significantly associated with a decreased risk of islet autoimmunity.